Age and sex, not APOE, drive brain volume changes in humanized APOE mice: A model of aging and risk, not disease

Abstract

Background: Whole brain and hippocampal atrophy are key structural features of late‐onset Alzheimer's disease (LOAD) and common clinical trial endpoints. The APOE ε4 allele is the strongest genetic risk factor, with ε4/ε4 genotype linked to the greatest atrophy rates.