AAIC 2025 Abstract
Multivariate non‐parametric GWAS identify novel variants linked to regional WMH via adhesion, membrane organization, and neurodevelopmental pathways
By Kahina Baouche, Patricia Genius, Blanca Rodríguez-Fernández, Show 7 more authorsNatàlia Vilor-Tejedor
Study in peopleMechanisms
Abstract
Background: White Matter Hyperintensities (WMH) are key radiological markers associated with cognitive decline and an increased risk of Alzheimer's disease (AD). Traditional genome‐wide association studies (GWAS) often overlook subtle genetic contributors to WMH burden due to their reliance on normal distribution assumptions.
