AAIC 2025 Abstract
Impaired glymphatic function exacerbates tau propagation and the effect of tau pathology on cognitive decline in Alzheimer's disease
By Ying Luan, Ying Cui, Jie Wang, Show 4 more authorsAlzheimer's Disease Neuroimaging Initiative (ADNI)
Study in peopleMechanisms
Abstract
Background: Tau protein aggregation is hypothesized to spread across interconnected neurons, where pathological tau is released from the presynaptic terminal via exocytosis and subsequently taken up by the postsynaptic neuron via endocytosis.
