AAIC 2025 Abstract
African‐origin protective haplotype for Alzheimer's disease in APOEε4 carriers
By Luciana Bertholim Nasciben, Derek Van Booven, Wanying Xu, Show 19 more authorsADSP (Alzheimer's Disease Sequencing Project)
Study in peopleMechanisms
Abstract
Background: We have reported a statistical interaction between the African ancestry specific A allele at rs10423769 and APOEε4 , where the presence of the A allele is associated with a reduction in AD risk up to 75% in APOEε4 homozygotes.
