AAIC 2025 Abstract

Characterization of a Mapt knock‐out rat: Sex‐dependent effects on LTP and object location memory

Experiments in animalsMechanisms

Abstract

Background: An emerging strategy for treating Alzheimer's disease is tau lowering therapeutics. These aim to reduce the levels of pathological tau species to prevent cognitive decline through approaches with RNA therapeutics, immunotherapy, small molecule inhibitors, or AAV‐based gene therapy.

The paper

Tanz Centre for Research in Neurodegenerative Diseases; University of Toronto

AAIC 2025 Abstract, 23 Dec 2025, CC BY

Presented at AAIC 2025

doi.org/10.1002/alz70855_102955