Apolipoprotein E (ApoE) 4 exacerbates pattern separation deficits and amyloid pathology in a combined humanized knock‐in Apolipoprotein E, Amyloid, and Tau model of Alzheimer's Disease

Abstract

Background: Cognitive deficits in Alzheimer's Disease (AD) are attributed to neuronal network disruptions associated with amyloid β and hyperphosphorylated tau aggregates. Pattern separation, the ability to store and differentiate between similar experiences, is linked to hippocampal function.

The paper