X Chromosome Genetic Risk Across Sex, APOE*4, and Pleiotropic Traits Reveals Novel Alzheimer's Disease Mechanisms and Risk Genes

Abstract

Background: Our group recently performed the largest‐to‐date X‐chromosome wide association study (XWAS) of Alzheimer's disease (AD). Here, we expand on this with additional samples, novel sex‐ and APOE *4‐stratified analyses, and evaluate escape from random X chromosome inactivation (eXCI) to better capture female‐biased risk genes.

The paper