X-editor

X-editor increases genome editing activity in N. primates (Compared with comparable preclinical data from Cas9-based therapies) (Greater editing at lower doses at two targets).

“At both targets, XE demonstrated greater editing at lower doses than comparable preclinical data from Cas9-based therapies that are now in clinical testing.”

AnimalsCompared with comparable preclinical data from Cas9-based therapieslipid nanoparticle mRNAliver

Gene editor achieved more editing at lower doses in primate liver

bioRxiv·Nov 12, 2026Preprint

X-editor increases genome editing activity in human cells (>100-fold higher editing activity).

“yielded an enzyme with more than 100-fold higher editing activity in human cells.”

Cellshuman cell

Gene editor achieved more editing at lower doses in primate liver

bioRxiv·Nov 12, 2026Preprint

X-editor showed no clear effect on off-target genome editing in human cells (Both guides assessed) (No off-target editing detected).

“No off-target editing was detected for either guide in full specificity assessments performed in primary human hepatocytes at doses tenfold above the on-target effective concentration (EC90).”

CellsBoth guides assessedprimary human hepatocytetenfold above the on-target effective concentration (EC90)

Gene editor achieved more editing at lower doses in primate liver

bioRxiv·Nov 12, 2026Preprint