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TA-1887

Intervention

1 paper4 findings

PubChem 24759836

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Japan Society for the Promotion of Science and 1 more
  • Animals1

Outcomes

4

Endothelial dysfunction

downin mice1

1 study

  1. TA-1887 protects against endothelial dysfunction in mice.

    “and antagonized endothelial dysfunction.”

    Animalsin high-fat diet-fed db/db mice

    Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality

    NPJ aging and mechanisms of disease8 Sep 2017

Cellular senescence

downin mice1

1 study

  1. TA-1887 decreases cellular senescence in mice.

    “Moreover, TA-1887 treatment attenuated inflammation, oxidative stress, and cellular senescence, especially in visceral white adipose tissue”

    Animalsin high-fat diet-fed db/db micevisceral white adipose tissue

    Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality

    NPJ aging and mechanisms of disease8 Sep 2017

More on Cellular senescence

Pancreatic beta cell death

downin mice1

1 study

  1. TA-1887 prevents pancreatic beta cell death in mice.

    “TA-1887 treatment prevented pancreatic beta cell death”

    Animalsin high-fat diet-fed db/db mice

    Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality

    NPJ aging and mechanisms of disease8 Sep 2017

Mortality

downin mice1

1 study

  1. TA-1887 decreases mortality in mice.

    “TA-1887-treated mice did not but rather continued to gain weight at later time points and decreased mortality.”

    Animalsin high-fat diet-fed db/db mice

    Treatment of diabetic mice with the SGLT2 inhibitor TA-1887 antagonizes diabetic cachexia and decreases mortality

    NPJ aging and mechanisms of disease8 Sep 2017

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