Sitting

1 paper5 findings

A human trial reported as a preprint finds that sitting impairs timed Up and Go performance and vitality, increases blood pressure after two hours, improves digit Symbol Substitution scores and leaves lower-limb power unchanged. All five findings come from one lab and name the British Geriatrics Society, Glasgow Caledonian University and Wellcome Trust as funders.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: British Geriatrics Society and 3 more

Human trial1

Outcomes

Vitality

downin humans1

1 study

Sitting impairs vitality in humans.
“Vitality declined across all sessions, but this was significantly worse after 4 h.”
Human trial
The ACUte effects of SITting time on physiological and psychological function in older adults (ACUSIT): An observational cohort study
medRxiv9 Sep 2026Preprint

Digit Symbol Substitution score

upin humans1

1 study

Sitting improves digit Symbol Substitution score in humans.
“Digit Symbol Substitution (DSS) scores (p=0.001) and % DSS correct scores (p<0.001) improved.”
Human trial
The ACUte effects of SITting time on physiological and psychological function in older adults (ACUSIT): An observational cohort study
medRxiv9 Sep 2026Preprint

Timed Up and Go performance

downin humans1

1 study

Sitting impairs timed Up and Go performance in humans.
“Timed Up & Go performance declined after all sessions of sitting (p=0.01)”
Human trial
The ACUte effects of SITting time on physiological and psychological function in older adults (ACUSIT): An observational cohort study
medRxiv9 Sep 2026Preprint

Blood pressure

upin humans1

1 study

Sitting increases blood pressure in humans.
“A significant increase in mean systolic and diastolic blood pressure was recorded following the 2h (systolic pre: 137 {+/-} 13, post: 141 {+/-} 6 mmHg; p<0.001; diastolic pre: 74 {+/-} 10, post 76 {+/-} 10mmHg; p<0.001)”
Human trial2 h
The ACUte effects of SITting time on physiological and psychological function in older adults (ACUSIT): An observational cohort study
medRxiv9 Sep 2026Preprint