SH045

Intervention

1 paper mentions it2 findings

PubChem

1 new paper in 30 daysSee all 1 papers on SH045

At a glance

The findings reach mice, none yet in people. 1 lab.

None of its findings points the other way.

Mice: a single group. Cells, worms or flies and humans: nothing yet.
  • 1 lab

What did studies of SH045 find?

2

Studies of SH045 measured 2 outcomes; the most studied are mesenteric artery constriction (1 study) and ryR-mediated calcium spark generation (1).

Mesenteric artery constriction

upin mice1

1 study
  1. SH045 induces mesenteric artery constriction in mice.

    “SH045 or SAR7334 also suppressed BK Ca currents and elicited constriction in mesenteric arteries from old mice.”

    Animalsmesenteric artery

    Calcium signals help limit artery narrowing in older mice

    Circulation research

RyR-mediated calcium spark generation

downin mice1

1 study
  1. SH045 decreases ryR-mediated calcium spark generation in mice.

    “Inhibiting TRPC6 with SH045 or SAR7334 suppressed RyR-mediated Ca 2+ spark generation in VSMCs from old mice but not young mice.”

    Animalsvascular smooth muscle cell

    Calcium signals help limit artery narrowing in older mice

    Circulation research

Latest

Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 0Nov 2026: 11 paper in 12 months
Circulation Research

Calcium signals help limit artery narrowing in older mice

Laboratory experiments in mice aged 12–14 months and 3–4 months identified a protein that helped move calcium-entry channels to the surface of older mice’s artery cells.Laboratory experiments in mice aged 12–14 months and 3–4 months identified a protein that helped move calcium-entry channels to the surface of older mice’s artery cells.

Mouse studyMechanisms