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Retinal ganglion cell ablation

Intervention

2 findings

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

Mice: a single group. Cells, worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: BrightFocus Foundation and 5 more

What did studies of retinal ganglion cell ablation find?

2

Studies of retinal ganglion cell ablation measured 2 outcomes; the most studied are ASCL1A and OLIG2 expression (1 study) and Differentiation of SOX10-EXPRESSING cells into post-mitotic retinal neurons (1).

ASCL1A and OLIG2 expression

upin zebrafish1

1 study

  1. Retinal ganglion cell ablation induces ASCL1A and OLIG2 expression in zebrafish.

    “after neuronal ablation they also express proneural factors including the ascl1a and olig2 genes”

    Animalsretina

    Mesenchymal-derived neural progenitors underlie local insulin production and neuronal transdifferentiation during retina regeneration

    bioRxiv : the preprint server for biologyPreprint

More on ASCL1A and OLIG2 expression

Differentiation of SOX10-EXPRESSING cells into post-mitotic retinal neurons

upin zebrafish1

1 study

  1. Retinal ganglion cell ablation induces differentiation of sox10-expressing cells into post-mitotic retinal neurons in the absence of cell proliferation.

    “we demonstrated that these cells can differentiate into post-mitotic retinal neurons in the ganglion cell layer (GCL) in the absence of cell proliferation”

    Animalsin the absence of cell proliferationganglion cell layer

    Mesenchymal-derived neural progenitors underlie local insulin production and neuronal transdifferentiation during retina regeneration

    bioRxiv : the preprint server for biologyPreprint