Optical ablation of pericytes
2 findings
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
Mice: a single group. Cells, worms or flies and humans: nothing yet.
- 1 lab in 1 country
- Funders: Alzheimer's Association and 8 more
What did studies of optical ablation of pericytes find?
2Studies of optical ablation of pericytes measured 2 outcomes; the most studied are capillary flow heterogeneity (1 study) and capillary dilation (1).
Capillary flow heterogeneity
upin mice1
1 study
Capillary flow heterogeneity
upin mice1
Optical ablation of pericytes increase capillary flow heterogeneity in mice (exacerbated in the aged brain).
“These abnormal dilations are exacerbated in the aged brain, and result in increased flow heterogeneity in capillary networks.”
Animalsexacerbated in the aged brainbrain capillaries
Nature communications
Capillary dilation
upin mice1
1 study
Capillary dilation
upin mice1
Optical ablation of pericytes increase capillary dilation in mice.
“Focal pericyte loss induces capillary dilation without blood-brain barrier disruption.”
Animalsbrain capillaries
Nature communications