Neurotransmitter-modulating supplement
Intervention1 paper4 findings
- Human trial1
Outcomes
4Sleep efficiency
upin humans1Moderate certainty
1 study
Sleep efficiency
upin humans1Moderate certainty
Neurotransmitter-modulating supplement improves sleep efficiency in humans (7.4% vs 3.4%).
Human trial3 weeksfemalesn = 127
Nonsedating neurotransmitter-modulating supplement for nonvasomotor sleep disturbance in menopause · Menopause (New York, N.Y.) · 15 Sep 2026
Total sleep time
upin humans1Moderate certainty
1 study
Total sleep time
upin humans1Moderate certainty
Neurotransmitter-modulating supplement increases total sleep time in humans (+40.9 minutes vs -14.9 minutes).
Human trial3 weeksfemalesn = 127
Nonsedating neurotransmitter-modulating supplement for nonvasomotor sleep disturbance in menopause · Menopause (New York, N.Y.) · 15 Sep 2026
Sleep-related impairment
downin humans1Moderate certainty
1 study
Sleep-related impairment
downin humans1Moderate certainty
Neurotransmitter-modulating supplement decreases sleep-related impairment in humans (-4.8 [95% CI, -7.3 to -2.3]).
Human trial3 weeksfemalesn = 127
Nonsedating neurotransmitter-modulating supplement for nonvasomotor sleep disturbance in menopause · Menopause (New York, N.Y.) · 15 Sep 2026
Sleep disturbance
downin humans1Moderate certainty
1 study
Sleep disturbance
downin humans1Moderate certainty
Neurotransmitter-modulating supplement decreases sleep disturbance in humans (LS mean difference: -11.1 [95% CI, -13.6 to -8.6]).
Human trial3 weeksfemalesn = 127
Nonsedating neurotransmitter-modulating supplement for nonvasomotor sleep disturbance in menopause · Menopause (New York, N.Y.) · 15 Sep 2026