Multidomain lifestyle programme

1. Multidomain lifestyle programme improves FACIT-F in humans (adjusted mean difference 1.9, 97.232% CI 0.4-3.4).

   Human trialin men on androgen deprivation therapy for prostate cancer versus optimised usual caresupervised aerobic and resistance exercise, dietary advice, behavioural support, gym membership12 monthsmalesn = 700

   An integrated lifestyle intervention for mitigation of adverse effects associated with androgen deprivation therapy for prostate cancer (STAMINA): a multicentre, randomised trial · The Lancet. Oncology · 4 Sep 2026

FACIT-F →

1. Multidomain lifestyle programme improves FACT-P in humans (adjusted mean difference 4.5, 97.232% CI 1.7-7.2).

   Human trialin men on androgen deprivation therapy for prostate cancer versus optimised usual caresupervised aerobic and resistance exercise, dietary advice, behavioural support, gym membership12 monthsmalesn = 700

   An integrated lifestyle intervention for mitigation of adverse effects associated with androgen deprivation therapy for prostate cancer (STAMINA): a multicentre, randomised trial · The Lancet. Oncology · 4 Sep 2026

FACT-P →

1. Multidomain lifestyle programme lowers the risk of liver disease deterioration in humans (HR = 0.91, 95%CI: 0.83–0.99).

   “Among participants who developed MASLD, the score was also associated with lower hazards of progression to liver disease deterioration (HR = 0.91, 95%CI: 0.83–0.99)”

   HumansAmong participants who developed MASLDEach 1-point increase13.6 yearsn = 3,371

   Dynamic Associations of a Multidimensional Healthy Lifestyle Score with the Incidence and Progression of Metabolic Dysfunction-associated Steatotic Liver Disease: Evidence from the UK Biobank · Research Square · 1 Sep 2026 · Preprint

Liver disease deterioration →

1. Multidomain lifestyle programme lowers the risk of mortality in humans (HR = 0.84, 95%CI: 0.84–0.85).

   “all-cause mortality from the baseline state (HR = 0.84, 95%CI: 0.84–0.85)”

   HumansEach 1-point increase13.6 yearsn = 286,000

   Dynamic Associations of a Multidimensional Healthy Lifestyle Score with the Incidence and Progression of Metabolic Dysfunction-associated Steatotic Liver Disease: Evidence from the UK Biobank · Research Square · 1 Sep 2026 · Preprint

1. Multidomain lifestyle programme lowers the risk of metabolic dysfunction-associated steatotic liver disease in humans (HR = 0.72, 95%CI: 0.71–0.74).

   “Each 1-point increase in the healthy lifestyle score was associated with lower hazards of incident MASLD (HR = 0.72, 95%CI: 0.71–0.74)”

   HumansEach 1-point increase13.6 yearsn = 286,000

   Dynamic Associations of a Multidimensional Healthy Lifestyle Score with the Incidence and Progression of Metabolic Dysfunction-associated Steatotic Liver Disease: Evidence from the UK Biobank · Research Square · 1 Sep 2026 · Preprint

Metabolic dysfunction-associated steatotic liver disease →