Studies of multicomponent exercise training in people

12 studies gave multicomponent exercise training to people and measured what changed

up: Improves short Physical Performance BatterySPPB β=0.60, 95% CI 0.22 to 0.98
down: Decreases TNF-alphaβ=-0.22, 95% CI -0.43 to -0.01
down: Decreases P3NP
Randomized trial57 peoplemean 84.4±6.7 years6 months
Older adults; with and without heart failure
European journal of heart failure, Apr 21, 2026
up: Improves physical function 13.0%
down: Decreases probable sarcopenia prevalence88.6% vs. 67.4%
Trial132 people The majority were men (61.3%)average age was 67.0 ± 5.8 years 1‐year
Community‐dwelling older adults with probable sarcopenia
Journal of aging research, Jan 1, 2026
up: Improves intrinsic capacity7.74 points, 95% CI 6.45–9.03
Randomized trial570 people87.3 ± 4.8 years1 year after discharge
Older adults; The oldest old; Acutely hospitalized older adults
Age and ageing, Mar 28, 2025
up: Improves cardiopulmonary reserve+3.32 mL/kg/min (95% CI 2.10-4.53; P < .001)
up: Improves right ventricular function+65.57 mL/s, P = .006; +56.39 mL/s, P = .026
Randomized trial120 peopleBoth65-85 years12 months
Older adults
Journal of the American Medical Directors Association, Jun 28, 2024
up: Improves cardiorespiratory fitnessp < .001
up: Improves upper limb strengthp = .017 to p < .001
Trial45 peopleWomen60-69 yearsten-month
Older adults; The oldest old
Research quarterly for exercise and sport, Feb 7, 2024
no change: Has no effect on handgrip strength
Randomized trial79 peopleBothaged 60 years or older 1 year
Community-dwelling, healthy older adults
European geriatric medicine, May 9, 2023
up: Improves muscle strength 234.31 ± 83.2 vs 210.07 ± 87.11 N·m
up: Increases muscle oxygen saturation
down: Decreases muscle oxygen saturation recovery inflection time7.07 ± 3.31s vs 8.73 ± 4.46s
Trial17 peopleyoung and older adults12 weeks
Young adults and healthy, community-dwelling older adults
Journal of exercise science and fitness, Dec 8, 2022
up: Improves quality of life Δ = 7.8, d = 0.45
down: Decreases frailtyΔ = −1.13, d = −0.45
down: Decreases sarcopeniaΔ = −0.64, d = −0.41
Trial52 people average 70.74 years of age 12 weeks
People ≥60 years of age, with treated and compensated multimorbidity, from a community center in an urban city in central Chile
International journal of environmental research and public health, Nov 28, 2022
up: Improves balance
no change: Has no effect on muscle strength
Randomized trial84 people5 months
Patient cohorts
International journal of sports medicine, Apr 13, 2022
no change: Has no effect on regucalcin r ranged from −0.04 to −0.33
no change: Has no effect on walking abilityr ranged from −0.04 to −0.33
no change: Has no effect on body composition
Trial20 people80.3 ± 6.1 years6 months (24 weeks)
Volunteers for limited function and being at risk of frailty
International journal of environmental research and public health, Dec 30, 2021
up: Improves physical function
up: Increases physical activity level
down: Decreases sedentary behavior
Trial41 peopleWomen67.4 ± 6.1 years12 weeks
Older adults
Journal of bodywork and movement therapies, Oct 8, 2021
down: Decreases emergency department visits4 vs 1, p:0.034
no change: Has no effect on mortality
down: Decreases frailty
Trial26 peopleBothmean 74.5 to 79 years10 weeks
Older adults; during adjuvant or palliative treatment
The Journal of frailty & aging, Jan 1, 2021