Mechanical stretching
1 paper3 findings
In a human cell study, progressive uniaxial mechanical stretching of engineered cardiac tubes containing hiPSC-derived cardiomyocytes and human foreskin fibroblasts improves cardiomyocyte alignment, sarcomere organisation and tissue contractility, and increases cardiac structural gene expression.
- 1 lab in 1 country
- Funder: Bundesministerium für Bildung und Forschung
- Cells1
Outcomes
3Cardiac structural gene expression
upin human cells1
1 study
Cardiac structural gene expression
upin human cells1
Mechanical stretching increases cardiac structural gene expression in human cells.
CellshiPSC-derived cardiomyocytes co-cultured with human foreskin fibroblastsprogressive uniaxial stretchengineered cardiac tube21% stretch20 days
Structural and functional remodeling of large-scale cardiac tubes
Biofabrication29 Sep 2026
Cardiomyocyte alignment and sarcomere organization
upin human cells1
1 study
Cardiomyocyte alignment and sarcomere organization
upin human cells1
Mechanical stretching improves cardiomyocyte alignment and sarcomere organization in human cells.
CellshiPSC-derived cardiomyocytes co-cultured with human foreskin fibroblastsprogressive uniaxial stretchengineered cardiac tube21% stretch20 days
Structural and functional remodeling of large-scale cardiac tubes
Biofabrication29 Sep 2026
Tissue contractility
upin human cells1
1 study
Tissue contractility
upin human cells1
Mechanical stretching improves tissue contractility in human cells.
CellshiPSC-derived cardiomyocytes co-cultured with human foreskin fibroblastsprogressive uniaxial stretchengineered cardiac tube21% stretch20 days
Structural and functional remodeling of large-scale cardiac tubes
Biofabrication29 Sep 2026