Molecular Therapy
Age had little effect on gene-silencing RNA activity in mice
One dose reduced target gene messages by more than 70% versus controls in several brain regions of both young and aged mice.One dose reduced target gene messages by more than 70% versus controls in several brain regions of both young and aged mice.
Mouse studyInterventions
Who was studiedYoung and aged mice, two weeks, against controls
What changedTarget gene messages fell by more than 70% in both young and aged mice compared with controls
The catchReductions in gene messages were molecular outcomes, not evidence of improved symptoms or slower disease