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(-)-gossypol

Intervention

1 paper3 findings

MeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Center for Research Resources and 4 more
  • Model organisms1

Outcomes

3

Age-dependent memory decline

downin worms1

1 study

  1. (-)-gossypol decreases age-dependent memory decline in worms.

    “treating aged worms with (-)- gossypol reversed physiological age-dependent memory decline”

    Model organisms

    (-)- Gossypol Inhibition of Musashi-Mediated Forgetting Improves Memory and Age-Dependent Memory Decline in Caenorhabditis elegans

    Molecular neurobiologyNov 15, 2022

msi-1

no changein worms1

1 study

  1. (-)-gossypol has no effect on msi-1 in worms.

    “we found no changes in MSI-1 protein abundance following (-)- gossypol treatment”

    Model organismspost-translational inhibition without altering gene expression

    (-)- Gossypol Inhibition of Musashi-Mediated Forgetting Improves Memory and Age-Dependent Memory Decline in Caenorhabditis elegans

    Molecular neurobiologyNov 15, 2022

More on msi-1

Memory retention

upin worms1

1 study

  1. (-)-gossypol improves memory retention in worms.

    “pharmacological inhibition of human MSI1 and MSI2 activity using (-)- gossypol resulted in improved memory retention”

    Model organisms

    (-)- Gossypol Inhibition of Musashi-Mediated Forgetting Improves Memory and Age-Dependent Memory Decline in Caenorhabditis elegans

    Molecular neurobiologyNov 15, 2022

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