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Gestational hypertension

Exposure

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 2 more
  • Humans1

Outcomes

3

White matter hyperintensities

upin humans1

1 study

  1. Gestational hypertension increases white matter hyperintensities in humans.

    “GH and preeclampsia were associated with greater white matter hyperintensities in the parietal and frontal lobes, respectively.”

    Humansparietal lobefemales

    Hypertensive Disorders of Pregnancy and Brain Health in Midlife: The CARDIA Study

    Hypertension (Dallas, Tex. : 1979)20 Aug 2024

Processing speed

downin humans1

1 study

  1. Gestational hypertension impairs processing speed in humans (mean change, -4.9 versus -2.7).

    “GH was associated with a greater 5-year decline in processing speed (mean change, -4.9 versus -2.7; P=0.049)”

    Humans5-yearfemales

    Hypertensive Disorders of Pregnancy and Brain Health in Midlife: The CARDIA Study

    Hypertension (Dallas, Tex. : 1979)20 Aug 2024

Global cognition

downin humans1

1 study

  1. Gestational hypertension impairs global cognition in humans (mean score, 23.2 versus 24.0).

    “GH was associated with worse cognitive performance: global cognition (mean score, 23.2 versus 24.0; P=0.018)”

    Humansfemales

    Hypertensive Disorders of Pregnancy and Brain Health in Midlife: The CARDIA Study

    Hypertension (Dallas, Tex. : 1979)20 Aug 2024

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