EFNA3-MAP
Intervention1 paper5 findings
One animal study shows EFNA3-MAP increases vaginal epithelial thickness and DSG1 in DMPA-treated mice and, with topical application, DMPA-treated rhesus macaques. It also reduces susceptibility to genital infection in the mice.
- Animals1
Outcomes
2Vaginal epithelial thickness
upin mice1upin rhesus monkeys1Very low certainty
1 study
Vaginal epithelial thickness
upin mice1upin rhesus monkeys1Very low certainty
EFNA3-MAP increases vaginal epithelial thickness in rhesus monkeys.
Animalsin DMPA-treated rhesus macaquestopicalvaginal epithelium
Targeting EphA2 with a novel EFNA3-mimetic peptide enhances vaginal epithelial barrier function: Running title: EFNA3-MAP enhancing the vaginal epithelial barrier · Mucosal immunology · 21 Sep 2026
EFNA3-MAP increases vaginal epithelial thickness in mice.
Animalsin DMPA-treated micevaginal epithelium
Targeting EphA2 with a novel EFNA3-mimetic peptide enhances vaginal epithelial barrier function: Running title: EFNA3-MAP enhancing the vaginal epithelial barrier · Mucosal immunology · 21 Sep 2026
DSG1
upin mice1upin rhesus monkeys1Very low certainty
1 study
DSG1
upin mice1upin rhesus monkeys1Very low certainty
EFNA3-MAP increases DSG1 in rhesus monkeys.
Animalsin DMPA-treated rhesus macaquestopicalvaginal epithelium
Targeting EphA2 with a novel EFNA3-mimetic peptide enhances vaginal epithelial barrier function: Running title: EFNA3-MAP enhancing the vaginal epithelial barrier · Mucosal immunology · 21 Sep 2026
EFNA3-MAP increases DSG1 in mice.
Animalsin DMPA-treated micevaginal epithelium
Targeting EphA2 with a novel EFNA3-mimetic peptide enhances vaginal epithelial barrier function: Running title: EFNA3-MAP enhancing the vaginal epithelial barrier · Mucosal immunology · 21 Sep 2026
Associations
1Susceptibility to genital infection
downin mice1Very low certainty
1 study
Susceptibility to genital infection
downin mice1Very low certainty
EFNA3-MAP lowers the risk of susceptibility to genital infection in mice.
Animalsin DMPA-treated mice
Targeting EphA2 with a novel EFNA3-mimetic peptide enhances vaginal epithelial barrier function: Running title: EFNA3-MAP enhancing the vaginal epithelial barrier · Mucosal immunology · 21 Sep 2026