Doxercalciferol

Doxercalciferol improves spine bone mineral density in humans (2.4%).

“and for spine BMD was 2.4% (p < 0.041).”

Human trialper-protocol analysisspine24 monthsfemales

Efficacy and safety of doxercalciferol (1α hydroxyvitamin D₂) on spine and femur bone mineral density in postmenopausal osteopenic women

Frontiers in endocrinology·23 Jul 2026

Doxercalciferol has no effect on spine bone mineral density in humans (1.1%).

“for spine BMD, the treatment/placebo difference was 1.1% (p = 0.36).”

Human trialintention-to-treat analysisspine24 monthsfemales

Efficacy and safety of doxercalciferol (1α hydroxyvitamin D₂) on spine and femur bone mineral density in postmenopausal osteopenic women

Frontiers in endocrinology·23 Jul 2026

Doxercalciferol improves femoral neck bone mineral density in humans (1.70%).

“At 24 months, there was a significant difference in favor of doxercalciferol for femoral neck BMD, with the treatment/placebo difference being 1.70% (p < 0.047)”

Human trialintention-to-treat analysisfemur24 monthsfemales

Efficacy and safety of doxercalciferol (1α hydroxyvitamin D₂) on spine and femur bone mineral density in postmenopausal osteopenic women

Frontiers in endocrinology·23 Jul 2026