Dauer diapause
Dauer diapause has been studied in 2 papers since 2018: none in people yet, 2 in animals. The research so far is in animals. The newest paper, Oct 7, 2019: “A hormone receptor pathway cell-autonomously delays neuron morphological aging by suppressing endocytosis”.
2 papers study it6 findingsUpdated
See all 2 papers on dauer diapause
At a glance
The findings reach worms or flies, none yet in people. 2 independent labs in 1 country.
None of its findings points the other way.
- 2 independent labs in 1 country
- Funders: National Institutes of Health and 6 more
- Model organisms2
What did studies of dauer diapause find?
6Studies of dauer diapause measured 6 outcomes; the most studied are constitutive endocytosis (1 study), gene expression plasticity (1) and lifespan (1).
constitutive endocytosis
downin worms1
1 study
constitutive endocytosis
downin worms1
Dauer diapause decreases constitutive endocytosis in worms.
“suppressed endocytosis appears to be a general feature of cells in diapause”
Model organisms
PLoS biology
Gene expression plasticity
downin worms1
1 study
Gene expression plasticity
downin worms1
Dauer diapause decreases gene expression plasticity in worms (transgenerational, in F3 progeny of postdauers).
“Further, postdauer F3 progeny exhibit reduced gene expression plasticity, suggesting a trade-off between plasticity and epigenetic memory”
Model organismstransgenerational, in F3 progeny of postdauers
Genetics
Lifespan
upin worms1
1 study
Lifespan
upin worms1
Dauer diapause extends lifespan in worms (transgenerational, in F3 progeny of postdauers).
“F3 progeny of postdauers display increased starvation resistance and lifespan”
Model organismstransgenerational, in F3 progeny of postdauers
Genetics
Starvation resistance
upin worms1
1 study
Starvation resistance
upin worms1
Dauer diapause increases starvation resistance in worms (transgenerational, in F3 progeny of postdauers).
“F3 progeny of postdauers display increased starvation resistance and lifespan”
Model organismstransgenerational, in F3 progeny of postdauers
Genetics
Interindividual variation
upin worms1
1 study
Interindividual variation
upin worms1
Dauer diapause increases interindividual variation in worms (postdauer worms after extended diapause).
“postdauer worms initially exhibit reduced reproductive success and greater interindividual variation”
Model organismspostdauer worms after extended diapause
Genetics
Reproductive success
downin worms1
1 study
Reproductive success
downin worms1
Dauer diapause decreases reproductive success in worms (postdauer worms after extended diapause).
“postdauer worms initially exhibit reduced reproductive success and greater interindividual variation”
Model organismspostdauer worms after extended diapause
Genetics