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Cognitive impairment without dementia

Cognitive impairment without dementia has been studied in 1 paper since 2018: 1 observational study in people. The newest paper, Nov 23, 2018: “Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and Cognition”.

Exposure

1 paper studies it3 findingsUpdated

See all 1 papers on cognitive impairment without dementia

At a glance

The findings reach people, from one lab or study. 1 lab in 1 country.

“only CIND = 26%, sub-hazard ratio [sHR] = 1.5, 95% confidence interval [CI] = 1.3-1.8”
Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and CognitionJournal of the American Geriatrics Society2018doi:10.1111/jgs.15683

None of its findings points the other way.

Humans: a single group. Cells, worms or flies and mice: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute on Aging and 3 more
  • Humans1

What did studies of cognitive impairment without dementia find?

1

Studies of cognitive impairment without dementia measured one outcome, Risk identification for ADL dependence.

Risk identification for ADL dependence

upin humans1

1 study

  1. Cognitive impairment without dementia is linked with better risk identification for ADL dependence in humans (added to a model that already included physical frailty) (Harrell's C 0.74 vs 0.71).

    “increased accuracy in identifying those at higher risk of ADL dependence (Harrell's concordance [C], 0.74 vs 0.71; P < .001)”

    Humansadded to a model that already included physical frailty8 years

    Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and Cognition

    Journal of the American Geriatrics Society

What is cognitive impairment without dementia linked with?

2

Studies link cognitive impairment without dementia with 2 measures: death and ADL dependence.

Death

upin humans1HR 1.6

1 study

  1. Cognitive impairment without dementia is linked with a higher risk of death in humans (HR 1.6, 95% CI 1.4-1.9; 41% vs 21% reference).

    “only CIND = 41%, HR = 1.6, 95% CI = 1.4-1.9”

    Humanscompared with no deficit, adjusted for sociodemographics, comorbidities, depression and smoking8 years

    Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and Cognition

    Journal of the American Geriatrics Society

ADL dependence

upin humans1

1 study

  1. Cognitive impairment without dementia is linked with a higher risk of ADL dependence in humans (sHR 1.5, 95% CI 1.3-1.8; 26% vs 14% reference).

    “only CIND = 26%, sub-hazard ratio [sHR] = 1.5, 95% confidence interval [CI] = 1.3-1.8”

    Humanscompared with no deficit, adjusted for sociodemographics, comorbidities, depression and smoking, death as competing risk8 years

    Assessing Risk for Adverse Outcomes in Older Adults: The Need to Include Both Physical Frailty and Cognition

    Journal of the American Geriatrics Society

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