C43-4

1 paper4 findings

C43-4 extends lifespan in worms and chronological lifespan in nondividing, quiescent yeast cells, and decreases MPS1 and CLB1 in yeast cells expressing C43-4. Results come from one lab, without independent replication. Funders include the Canadian Institutes of Health Research and Natural Sciences and Engineering Research Council of Canada.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Canadian Institutes of Health Research and 4 more

Cells1

Outcomes

MPS1

downin yeast cells1

1 study

C43-4 decreases MPS1 in yeast cells.
Cellsin cells expressing C43-4
Discovery of a small peptide that increases yeast lifespan by enhancing the function of APCCdh1 in nondividing quiescent cells
Genetics16 Sep 2026

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Genetics16 Sep

Discovery of a small peptide that increases yeast lifespan by enhancing the function of APCCdh1 in nondividing quiescent cells

Experiments in yeastInterventions

Paper

C43-4

Outcomes

Latest

Discovery of a small peptide that increases yeast lifespan by enhancing the function of APCCdh1 in nondividing quiescent cells

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