C1-27

1. C1-27 increases amyloid precursor protein in mice.

   Animalscombined with surgical traumahippocampus

   Spatiotemporal Characterization of GSTO1 Inhibition in Postoperative Cognitive Dysfunction: Roles of Hippocampal Oxidative Stress and Neuroinflammation in Aged Mice · Research Square · 8 Sep 2026 · Preprint

Amyloid precursor protein →

1. C1-27 impairs spatial memory in mice.

   Animalscombined with surgical traumahippocampuspostoperative day 3 and day 7

   Spatiotemporal Characterization of GSTO1 Inhibition in Postoperative Cognitive Dysfunction: Roles of Hippocampal Oxidative Stress and Neuroinflammation in Aged Mice · Research Square · 8 Sep 2026 · Preprint

1. C1-27 decreases GSH/GSSG ratio in mice.

   Animalscombined with surgical traumahippocampus

   Spatiotemporal Characterization of GSTO1 Inhibition in Postoperative Cognitive Dysfunction: Roles of Hippocampal Oxidative Stress and Neuroinflammation in Aged Mice · Research Square · 8 Sep 2026 · Preprint

GSH/GSSG ratio →