Area deprivation index
3 papers6 findings
- 2 independent labs in 2 countries
- Humans3
Outcomes
2pTau-217
no changein humans1
1 study
pTau-217
no changein humans1
Area deprivation index has no effect on pTau-217 in humans.
“No significant relationships were observed between ADI tertiles and pTau217.”
Humansn = 1,099
AAIC 2025 abstract23 Dec 2025
Amyloid-beta
no changein humans1
1 study
Amyloid-beta
no changein humans1
Area deprivation index has no effect on amyloid-beta in humans.
“No associations between ADI and amyloid status were found across cohorts.”
Humansacross cohortsn = 3,091
Sociodemographic associations with AD biomarkers in POINTER, UBRAIN, and ADNI
AAIC 2025 abstract23 Dec 2025
Associations
4Aβ42/Aβ40 ratio
downin humans1
1 study
Aβ42/Aβ40 ratio
downin humans1
Area deprivation index is associated with Aβ42/Aβ40 ratio in humans (difference: 0.00328 (p = 0.041)).
“and lower Aβ 42/40 [difference (p value): 0.00328 (0.041)], compared to those in the lowest ADI tertile.”
Humansn = 1,099
AAIC 2025 abstract23 Dec 2025
GFAP
upin humans1
1 study
GFAP
upin humans1
Area deprivation index is associated with GFAP in humans (difference: 10.26 (p = 0.044)).
“and GFAP [difference (p value): 10.26 (0.044)]”
Humansn = 1,099
AAIC 2025 abstract23 Dec 2025
NfL
upin humans1
1 study
NfL
upin humans1
Area deprivation index is associated with NfL in humans (difference: 1.37 (p = 0.033)).
“Participants living in the highest ADI areas exhibited higher NfL [difference (p value): 1.37 (0.033)]”
Humansn = 1,099
AAIC 2025 abstract23 Dec 2025
PACC-5
downin humans1
1 study
PACC-5
downin humans1
Area deprivation index is associated with PACC-5 in humans (β = -0.412, p < 0.001).
“higher ADI was associated with lower PACC in U.S. POINTER (Moderate: β=‐0.165, p <0.001; High β=‐0.412, p <0.001)”
Humansadjusted by sex, age, and APOE4n = 1,879
Sociodemographic associations with AD biomarkers in POINTER, UBRAIN, and ADNI
AAIC 2025 abstract23 Dec 2025