Anti-crf antibody

Intervention1 paper4 findings

  • Animals1

Outcomes

4

Insulin sensitivity

upin mice1Very low certainty

1 study
  1. Anti-crf antibody improves insulin sensitivity in mice.

    Animalsmonoclonal antibody

    Antibody reduced fat while preserving lean mass in mice · JCI insight · 6 Oct 2026

Lean mass

no changein mice1Very low certainty

1 study
  1. Anti-crf antibody has no effect on lean mass in mice.

    Animalsmonoclonal antibody

    Antibody reduced fat while preserving lean mass in mice · JCI insight · 6 Oct 2026

Fat mass

downin mice1Very low certainty

1 study
  1. Anti-crf antibody decreases fat mass in mice.

    Animalsmonoclonal antibody

    Antibody reduced fat while preserving lean mass in mice · JCI insight · 6 Oct 2026

Corticosterone

downin mice1Very low certainty

1 study
  1. Anti-crf antibody decreases corticosterone in mice.

    Animalsmonoclonal antibody

    Antibody reduced fat while preserving lean mass in mice · JCI insight · 6 Oct 2026

Corticosterone →

Latest

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JCI InsightAnimals

Antibody reduced fat while preserving lean mass in mice

Experiments in middle-aged and aged mice found that an antibody targeting a stress-hormone signal reduced fat mass without reducing lean mass.Experiments in middle-aged and aged mice found that an antibody targeting a stress-hormone signal reduced fat mass without reducing lean mass.