Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA
Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA has been studied in 1 paper since 2026: 1 trial in people; 1 in the past year. The newest paper, Feb 14, 2026: “Effects of a Capsule Containing Clostridium butyricum, 3-(4-Hydroxy-3-Methoxyphenyl)propionic Acid, and Salmon Milt-Derived DNA on Cognitive Function in Middle-Aged and Older Adults: A 12-Week Randomized, Double-Blind, Placebo-Controlled Trial”.
1 paper studies it4 findingsUpdated
“In the overall analysis, no significant difference was observed in Composite Memory between groups”
None of its findings points the other way.
- 1 lab in 1 country
- 4 of 4 findings with company ties
- Human trial1
Studies in people
1 study gave clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA to people and measured what changed.
no change: Has no effect on Composite Memory
up: Improves Symbol Digit Coding test
up: Improves verbal memory
Randomized trial80 peopleBoth55–79 years12 weeks
Midlife adults; Older adults; MMSE-J scores of 24–27
Preprints.org, Feb 14, 2026
What did studies of Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA find?
4Studies of Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA measured 4 outcomes; the most studied are fasting blood glucose (1 study), verbal memory (1) and Symbol Digit Coding test (1).
Fasting blood glucose
downin humans1
1 study
Fasting blood glucose
downin humans1
Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA decreases fasting blood glucose in humans.
“Exploratory evaluations showed significant improvements in metabolic markers such as fasting plasma glucose, HbA1c, γ-GT, and uric acid in the Test food group”
Human trialcapsule containing 1.4 × 107 CFU C. butyricum, 11.5 mg HMPA, 45 mg salmon milt-derived DNA12 weeksn = 80
Preprints.orgPreprint
Verbal memory
upin humans1
1 study
Verbal memory
upin humans1
Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA improves verbal memory in humans (MMSE-J scores of 24–27).
“In the subgroup analysis, significant improvements in verbal memory-related indices were observed in the Test food group”
Human trialMMSE-J scores of 24–27capsule containing 1.4 × 107 CFU C. butyricum, 11.5 mg HMPA, 45 mg salmon milt-derived DNA12 weeks
Preprints.orgPreprint
Symbol Digit Coding test
upin humans1
1 study
Symbol Digit Coding test
upin humans1
Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA improves Symbol Digit Coding test in humans.
“the number of correct responses in the Symbol Digit Coding (SDC) test, which is related to attention and processing speed, significantly improved in the Test food group”
Human trialcapsule containing 1.4 × 107 CFU C. butyricum, 11.5 mg HMPA, 45 mg salmon milt-derived DNA12 weeksn = 80
Preprints.orgPreprint
Composite Memory
no changein humans1
1 study
Composite Memory
no changein humans1
Clostridium butyricum + 3-(4-hydroxy-3-methoxyphenyl)propionic acid + salmon milt-derived DNA showed no clear effect on Composite Memory in humans.
“In the overall analysis, no significant difference was observed in Composite Memory between groups”
Human trialcapsule containing 1.4 × 107 CFU C. butyricum, 11.5 mg HMPA, 45 mg salmon milt-derived DNA12 weeksn = 80
Preprints.orgPreprint