bioRxiv
Cell recycling defect caused brain shrinkage in aging mice
Yearlong experiments in over 140 mice found an Alzheimer’s-like pattern of brain shrinkage after disruption of a system that recycles material inside cells.Yearlong experiments in over 140 mice found an Alzheimer’s-like pattern of brain shrinkage after disruption of a system that recycles material inside cells.
Preprint: mouse studyMechanisms
Who was studiedSORL1-deficient and wildtype mice, yearlong, against wildtype littermates
What changedSORL1-deficient mice had more brain shrinkage than wildtype mice, centered on the trans-entorhinal cortex
The catchThe longitudinal MRI study had only fourteen, nine, and ten mice in its genotype groups