Experimental Neurology
Alzheimer’s risk variant mildly altered brain immune cells in mice
Experiments in Alzheimer’s-model mice aged 18 or 24 months found that a risk variant had different effects from complete loss of the gene.Experiments in Alzheimer’s-model mice aged 18 or 24 months found that a risk variant had different effects from complete loss of the gene.
Mouse studyMechanisms
Who was studiedAged AppNL-F mice, against mice lacking Trem2
What changedMice carrying the variant showed mild microglial changes, distinct from deficits seen in mice lacking Trem2
The catchMicroglial gene activity was measured; cognitive function and memory were not