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mbl-1

Gene

3 papers3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 2 countries
  • Funders: Academy of Finland and 5 more
  • Model organisms3

Effects

2

Lifespan

is required forin worms1downin worms1

2 studies

  1. mbl-1 is required for lifespan in worms.

    “short MBL-1 isoforms are crucial regulators of miRNA expression and, in consequence, required for normal lifespan.”

    Model organismsisoform-specific CRISPR/Cas9 mutant

    The Muscleblind-like protein MBL-1 regulates microRNA expression in Caenorhabditis elegans through an evolutionarily conserved autoregulatory mechanism

    PLoS geneticsDec 22, 2023

  2. mbl-1 shortens lifespan in worms.

    “exc-7; mbl-1 double mutants have strongly reduced lifespan”

    Model organismsdouble mutant

    A pair of RNA binding proteins inhibit ion transporter expression to maintain lifespan

    bioRxiv : the preprint server for biologyJun 23, 2023Preprint

Neuromuscular function

is required forin worms1

1 study

  1. mbl-1 is required for neuromuscular function in worms.

    “expression of short MBL-1 protein isoforms is required for healthy neuromuscular function”

    Model organismsisoform-specific CRISPR/Cas9 mutant

    The Muscleblind-like protein MBL-1 regulates microRNA expression in Caenorhabditis elegans through an evolutionarily conserved autoregulatory mechanism

    PLoS geneticsDec 22, 2023

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