There is 1 paper on MAPTMUTATION in aging research: 1 observational study in people.
1 paper studies it2 findings
“Two years later, MAPT mutation carriers showed a steeper decline than GRN mutation carriers on social cognition (p = 0.002).”
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Dioraphte Foundation and 1 more
- Humans1
Associations
2Language and social cognition decline before symptom onset
downin humans1
1 study
Language and social cognition decline before symptom onset
downin humans1
MAPTMUTATION is associated with language and social cognition decline before symptom onset in humans (7 to 5 years before estimated symptom onset).
“language and social cognition declined only in MAPT mutation carriers from 7 to 5 years before estimated symptom onset, respectively (p < 0.05).”
Humans7 to 5 years before estimated symptom onset
Presymptomatic cognitive decline in familial frontotemporal dementia: A longitudinal study
Neurology
Social cognition decline
downin humans1
1 study
Social cognition decline
downin humans1
MAPTMUTATION is associated with social cognition decline in humans (over 2 years, versus GRN mutation carriers).
“Two years later, MAPT mutation carriers showed a steeper decline than GRN mutation carriers on social cognition (p = 0.002).”
Humansover 2 years, versus GRN mutation carriers2 years
Presymptomatic cognitive decline in familial frontotemporal dementia: A longitudinal study
Neurology