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CYP2C6

Gene

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 1 more
  • Animals1

Interventions

1

Phenobarbital

upin rats1

1 study

  1. Phenobarbital increases CYP2C6 in rats.

    “At 2 yr of age, in agreement with an overexpression of hepatic CYP2C6 and CYP2C7, both in vitro and in vivo drug metabolism was more rapid”

    Animalsliver

    Neonatal phenobarbital imprints overexpression of cytochromes P450 with associated increase in tumorigenesis and reduced life span

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology5 Jan 2005

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