CFHR5
5 papers study it4 findings
None of its findings points the other way.
- 2 independent labs in 2 countries
- Funders: Alnylam Pharmaceuticals and 3 more
- 4 of 4 findings with company ties
- Humans5
Effects
1Photoreceptor layer outer segment thickness
upin humans1
1 study
Photoreceptor layer outer segment thickness
upin humans1
CFHR5 increases photoreceptor layer outer segment thickness in humans (+0.34 SD, p = 4 × 10−4).
“CFHR5 rare variant burden is significantly associated with increased thickness of this retinal layer (+0.34 SD, p = 4 × 10−4, n = 45,365).”
Humansrare variant burdenn = 45,365
American journal of human genetics
Associations
2Age-related macular degeneration
downin humans2OR 0.75
2 studies
Age-related macular degeneration
downin humans2OR 0.75
CFHR5 lowers the risk of age-related macular degeneration in humans (OR = 0.75, p = 7 × 10−4).
“CFHR5 rare variant burden significantly associates with a decreased risk of broadly defined AMD (odds ratio [OR] = 0.75, p = 7 × 10−4)”
Humansrare variant burden
American journal of human genetics
CFHR5 lowers the risk of age-related macular degeneration in humans (OR=0.75, p=7×10 −4).
“CFHR5 rare variant burden significantly associates with decreased risk of AMD (OR=0.75, p=7×10 −4 )”
Humansadjusting for CFH-region variants
medRxivPreprint
Complement system
upin humans1
1 study
Complement system
upin humans1
CFHR5 is associated with complement system in humans.
“Genetic reduction in FHR-5 correlates with higher preserved activities of the classical and alternative complement pathways”
Humansgenetic reduction in FHR-5
Loss of CFHR5 function reduces the risk for age-related macular degeneration
medRxiv : the preprint server for health sciencesPreprint