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alg-1

Gene

1 paper3 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico and 7 more
  • Model organisms1

Effects

2

Survival against pro-oxidant agents

upin worms1

1 study

  1. alg-1 improves survival against pro-oxidant agents in worms.

    “while overexpression enhances survival against pro-oxidant agents but not heat or reductive stress”

    Model organismsoverexpression

    An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress

    Nature communicationsApr 9, 2024

Oxidative stress and ROS signalling

downin worms1

1 study

  1. alg-1 protects against oxidative stress and ROS signalling in worms.

    “ALG-1 knockdown reduces lifespan and oxidative stress resistance”

    Model organismsshown by knockdown

    An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress

    Nature communicationsApr 9, 2024

More on Oxidative stress and ROS signalling

Upstream

1

R02D3.7

downin worms1

1 study

  1. R02D3.7 inhibits alg-1 in worms.

    “R02D3.7 represses alg-1 expression, impacting oxidative stress resistance at least in part via ALG-1.”

    Model organismsshown by repression of alg-1

    An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress

    Nature communicationsApr 9, 2024

More on R02D3.7

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