ACADS

1. ACADS inhibits lipophagy in mice.

   “the autophagic degradation of lipid droplets, which was not detected in elderly wild-type mice, was maintained in SCAD-deficient old mice.”

   Animalsshown by SCAD deletion compared with wild-type miceliver

   Aging-induced short-chain acyl-CoA dehydrogenase promotes age-related hepatic steatosis by suppressing lipophagy

   Aging cell·19 Jun 2024

1. ACADS increases hepatic steatosis in mice.

   “Our further evidence in SCAD-ablated mice suggested that SCAD deletion was able to slow liver aging and ameliorate aging-associated fatty liver.”

   Animalsshown by SCAD deletionliver

   Aging-induced short-chain acyl-CoA dehydrogenase promotes age-related hepatic steatosis by suppressing lipophagy

   Aging cell·19 Jun 2024

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