Cancer
Prostate screening trade-offs worsen with age in models
Models estimated 2.7–3.1 overdiagnoses per prostate cancer death prevented at 72 versus 4.5–5.1 at 76 in men without other illnesses.Models estimated 2.7–3.1 overdiagnoses per prostate cancer death prevented at 72 versus 4.5–5.1 at 76 in men without other illnesses.
Computational studyInterventions
Who was studiedSimulated men without diagnosed prostate cancer, lifetime
What changedIn men without comorbidities, overdiagnoses per cancer death prevented rose from 2.7–3.1 at age 72 years to 4.5–5.1 at age 76 years
The catchMRI and targeted biopsy accuracy were assumed constant across ages and comorbidity groups