Brain, Behavior, and Immunity
Aged mice changed behavior after sepsis without broad inflammation
Researchers followed three-month-old and 18-month-old mice through seven days after sepsis; aged mice showed altered nesting and social behavior despite comparable…Researchers followed three-month-old and 18-month-old mice through seven days after sepsis; aged mice showed altered nesting and social behavior despite comparable illness severity.
Mouse studyInflammation
Who was studiedYoung and aged mice, through Day 7, against young septic mice
What changedAged mice changed nesting and social behavior without broad inflammation; young mice remained behaviorally resilient
The catchBrain measurements on day eight could miss an earlier inflammatory contribution to behavioral changes