WOMAC pain score

Biomarker

1 paper1 finding

Interventions

Semaglutide

downin humans1

1 study

Semaglutide decreases WOMAC pain score in humans (-41.7 points vs -27.5 points placebo).
ReviewSTEP 9 trial2.4 mg68 weeksn = 407
Glucagon-like Peptide-1 Receptor Agonists and Chronic Pain: Preclinical Antinociceptive Mechanisms, Indirect Metabolic-Functional Effects, and Clinical Considerations-A Narrative Review
Journal of clinical medicine29 Jul 2026

Latest

2 in 12 months

The New England Journal of Medicine1 Oct

Retatrutide reduces weight and pain in adults with obesity

Mean body weight fell up to 25.0% with retatrutide versus 3.9% on placebo over 80 weeks in adults with obesity.Mean body weight fell up to 25.0% with retatrutide versus 3.9% on placebo over 80 weeks in adults with obesity.

Randomised trial in 2,339 peopleRetatrutide

Paper

Journal of Clinical Medicine13 Aug

Glucagon-like Peptide-1 Receptor Agonists and Chronic Pain: Preclinical Antinociceptive Mechanisms, Indirect Metabolic-Functional Effects, and Clinical Considerations-A Narrative Review

ReviewGLP-1 receptor agonists