SFCN-reg brain age

SFCN-reg brain age predicts cognitive function in humans.

“Both clocks were associated with faster decline in global cognition over time.”

Humansolder Latinos in RADC cohortbrainn = 125

MRI‐derived biologic clocks and cognitive aging in a sample of older Latino adults · AAIC 2025 abstract · 25 Dec 2025

SFCN-reg brain age is associated with cognitive function in humans (-0.028-unit reduction in baseline global cognitive scores).

“Each one‐year increment in SFCN‐reg brain age corresponded to a 0.028‐unit reduction in baseline global cognitive scores ( p = 0.01) for the regular clock”

Humansolder Latinos in RADC cohortbrainn = 125

MRI‐derived biologic clocks and cognitive aging in a sample of older Latino adults · AAIC 2025 abstract · 25 Dec 2025