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Phenotypic AgeAccel

Biomarker

1 paper2 findings

  • Humans1

Effects

1

Mortality

mediatesin humans1

1 study

  1. Phenotypic AgeAccel mediates mortality in humans (23.53% of total effect on all-cause mortality, 15.73% of CVD mortality).

    “slower PhenoAgeAccel, with mediation effects accounting for 23.53% and 15.73% of the total impact on all-cause and CVD mortality, respectively.”

    Humanscardiovascular-kidney-metabolic syndrome stages 1 to 4

    Association of estimated glucose disposition rate with aging acceleration and mortality risk in individuals with cardiovascular-kidney-metabolic syndrome: evidence from two large national population-based studies

    Cardiovascular diabetology22 Oct 2025

Upstream

1

Estimated glucose disposal rate

downin humans1OR 0.78

1 study

  1. Estimated glucose disposal rate decreases phenotypic AgeAccel in humans (OR 0.78, 95% CI 0.75-0.80).

    “PhenoAgeAccel (OR = 0.78, 95% CI 0.75-0.80).”

    Humanscardiovascular-kidney-metabolic syndrome stages 1 to 4

    Association of estimated glucose disposition rate with aging acceleration and mortality risk in individuals with cardiovascular-kidney-metabolic syndrome: evidence from two large national population-based studies

    Cardiovascular diabetology22 Oct 2025

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