Journal of Neurology
Sleep tests and brain scans point to different disease stages
A retrospective study of 86 patients linked sleep disruptions to later disease development and widespread brain shrinkage to established disease.A retrospective study of 86 patients linked sleep disruptions to later disease development and widespread brain shrinkage to established disease.
Cohort · 86 peopleBiomarkers
Who was studied86 patients with iRBD or established α-synucleinopathy
What changedPatients developing disease had more sleep disruptions but similar brain structure to those remaining disease-free; established disease involved brain shrinkage
The catchOnly 25 patients developed disease, limiting comparisons across disease stages