NfL-derived age

1. Multiple sclerosis increases NfL-derived age in humans (OR = 1.44; 95% CI 1.10-1.87; p = 0.007).

   “PwMS showed a higher likelihood than controls of having a NfL-derived age above their chronological age (OR = 1.44;95%CI 1.10-1.87; p = 0.007).”

   Humanscompared to controls

   Evaluating the neurofilament light chain-derived gap between biological and chronological age in multiple sclerosis and controls · Journal of neurology · 27 Sep 2026

Multiple sclerosis →

1. Disability is associated with NfL-derived age in humans.

   “MS is associated with a shift in age-associated NfL trajectory, with an older biological profile especially in pwMS with greater disability and progressive course.”

   Humansin pwMS

   Evaluating the neurofilament light chain-derived gap between biological and chronological age in multiple sclerosis and controls · Journal of neurology · 27 Sep 2026