medRxiv
Reference size complicates genetic findings in Lebanese adults
A size-matched reference missed Lebanese participants’ genetic variants no more often than one cohort half missed the other, with a ratio of 0.98.A size-matched reference missed Lebanese participants’ genetic variants no more often than one cohort half missed the other, with a ratio of 0.98.
Preprint: cross-sectional · 199 peopleAI & data
Who was studied199 older Lebanese adults, against one half of the cohort
What changedThe size-matched reference missed Lebanese genetic variants no more often than a cohort half did (ratio 0.98)
The catchFounder alleles also confound variant interpretation, complicating attribution of missing variants to reference size alone