Kidney Δage

1. Hippuric acid decreases kidney Δage in humans (β: -0.009, 95% CI: -0.015, -0.003).

   “The MR analysis further support a causal relationship between the HPA and kidney Δage (β: -0.009, 95% CI: -0.015, -0.003).”

   HumansMendelian randomization

   Integrating Genetics And Metabolomics Reveals Putative Mechanisms For Hippuric acid Delaying Kidney Aging · GSA 2025 abstract · 31 Dec 2025

Hippuric acid →

1. Hippuric acid is associated with kidney Δage in humans (β: -0.794, 95% CI: -1.352, -0.235).

   “Plasma HPA levels were positively associated with chronological age and liver Δage, but negatively correlated with Δage of heart, kidney (β: -0.794, 95% CI: -1.352, -0.235), and vascular.”

   Humansplasman = 777

   Integrating Genetics And Metabolomics Reveals Putative Mechanisms For Hippuric acid Delaying Kidney Aging · GSA 2025 abstract · 31 Dec 2025

Hippuric acid →