iPRS

1. iPRS lowers the risk of celiac disease in humans (OR = 0.713, p = 2.98 × 10−46).

   Humansadjusted for sex, age, EHR length, race, ethnicity, and PCsn = 265,068

   Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes · HGG advances · 4 Sep 2026

Celiac disease →

1. iPRS raises the risk of rheumatoid arthritis in humans (OR = 1.09, p = 1.02 × 10−13).

   Humansadjusted for sex, age, EHR length, race, ethnicity, and PCsn = 265,068

   Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes · HGG advances · 4 Sep 2026

Rheumatoid arthritis →

1. iPRS raises the risk of hypertension in humans (OR = 1.04, p = 4.56 × 10−15).

   Humansadjusted for sex, age, EHR length, race, ethnicity, and PCsn = 265,068

   Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes · HGG advances · 4 Sep 2026

Hypertension →

1. iPRS raises the risk of ankylosing spondylitis in humans (OR = 1.4, p = 1.33 × 10−17).

   Humansadjusted for sex, age, EHR length, race, ethnicity, and PCsn = 265,068

   Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes · HGG advances · 4 Sep 2026

Ankylosing spondylitis →

1. iPRS predicts INFLA-score in humans (R2 = 0.026, beta = 0.980, p < 2 × 10−16).

   Humansadjusted for age, sex, and genetically determined principal componentsn = 4,833

   Inherited predisposition to increased systemic inflammation predicts a broad class of disease phenotypes · HGG advances · 4 Sep 2026

INFLA-score →