Impaired intrinsic capacity

1. Impaired intrinsic capacity raises the risk of stroke in humans (pooled: HR 1.85, 95% CI 1.48-2.32).

   “These relationships were most significant for stroke (CHARLS: HR 1.78, 95% CI 1.28-2.46; KLoSA: HR 1.51, 95% CI 1.05-2.19; ELSA: HR 2.23, 95% CI 1.22-4.09; pooled: HR 1.85, 95% CI 1.48-2.32; I2 = 0.0%, p = 0.740).”

   Humansadjusted for confounders

   Associations of intrinsic capacity and social isolation with cardiometabolic diseases: A prospective multi-cohort study

   Maturitas·Apr 6, 2026

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1. Impaired intrinsic capacity raises the risk of cardiometabolic disease in humans (HR 1.25, 95% CI 1.12-1.39).

   “"impaired" IC participants (CHARLS: hazard ratio [HR] 1.25, 95% confidence interval [CI] 1.12-1.39) and "pre-impaired" IC participants (ELSA: HR 1.26, 95% CI 1.08-1.46) had significantly elevated risks of incident CMD”

   Humansadjusted for confounders

   Associations of intrinsic capacity and social isolation with cardiometabolic diseases: A prospective multi-cohort study

   Maturitas·Apr 6, 2026

More on Cardiometabolic disease