There are 5 papers on HFA-PEFF score in aging research: 5 observational studies in people.
5 papers study it6 findings
3 new papers in 30 daysSee all 5
“participants with a high probability of HFpEF had more than double the risk of hospitalization for HF”
- Humans5
Effects
1Atrioventricular block and atrial tachyarrhythmias other than atrial fibrillation
no changein humans1
1 study
Atrioventricular block and atrial tachyarrhythmias other than atrial fibrillation
no changein humans1
HFA-PEFF score was not clearly linked with atrioventricular block and atrial tachyarrhythmias other than atrial fibrillation in humans.
“No significant association was observed between the HFA-PEFF score and atrioventricular block or atrial tachyarrhythmias other than AF.”
HumansNo prior atrial fibrillation; insertable cardiac monitor implantation for recurrent unexplained syncopeMedian follow-up 35 months34% womensn = 164
ESC Congress 2026 abstract
More on Atrioventricular block and atrial tachyarrhythmias other than atrial fibrillation
Associations
5Atrial fibrillation
upin humans1HR 1.94
1 study
Atrial fibrillation
upin humans1HR 1.94
HFA-PEFF score is associated with atrial fibrillation in humans (HR 1.94, 95% CI 1.40–2.67).
“LV diastolic dysfunction assessed by the HFA-PEFF score is independently associated with the de novo development of SSS and AF”
HumansNo prior atrial fibrillation; insertable cardiac monitor implantation for recurrent unexplained syncope; AF episodes lasting ≥6 minutes; multivariable adjustmentMedian follow-up 35 months34% womensn = 164
ESC Congress 2026 abstract
Sick sinus syndrome
upin humans1HR 1.51
1 study
Sick sinus syndrome
upin humans1HR 1.51
HFA-PEFF score is associated with sick sinus syndrome in humans (HR 1.51, 95% CI 1.07–2.13).
“The HFA-PEFF score was independently associated with SSS (hazard ratio [HR] 1.51, 95% confidence interval [CI] 1.07–2.13; p=0.021)”
HumansNo prior atrial fibrillation; insertable cardiac monitor implantation for recurrent unexplained syncope; multivariable adjustmentMedian follow-up 35 months34% womensn = 164
ESC Congress 2026 abstract
Cardiac arrhythmia hospitalization
upin humans1HR 1.5
1 study
Cardiac arrhythmia hospitalization
upin humans1HR 1.5
HFA-PEFF score predicts cardiac arrhythmia hospitalization in humans (COPD without known HF, adjusted for age, sex, and FEV1% predicted) (HR 1.5 [1.04–2.3], p=0.033).
“1.5-fold increased risk of hospitalization for cardiac arrhythmias compared with those with low-to-intermediate HFpEF probability”
HumansCOPD without known HF, adjusted for age, sex, and FEV1% predictedmedian 3.0 yearsn = 701
ESC Congress 2026 abstract
Heart failure hospitalization
upin humans1HR 2.1
1 study
Heart failure hospitalization
upin humans1HR 2.1
HFA-PEFF score predicts heart failure hospitalization in humans (COPD without known HF, adjusted for age, sex, and FEV1% predicted) (HR 2.1 [95% CI 1.03–4.4], p=0.042).
“participants with a high probability of HFpEF had more than double the risk of hospitalization for HF”
HumansCOPD without known HF, adjusted for age, sex, and FEV1% predictedmedian 3.0 yearsn = 701
ESC Congress 2026 abstract
Skin autofluorescence
upin humans1
1 study
Skin autofluorescence
upin humans1
Skin autofluorescence is associated with HFA-PEFF score in humans (univariable regression) (beta 0.27, 95% CI 0.10-0.43).
“SAF was related to HFA-PEFF score (0.27, 95% CI = 0.10-0.43)”
Humansunivariable regressionn = 245
Nutrition, metabolism, and cardiovascular diseases : NMCD