Circulation Genomic and Precision Medicine
Genetics linked to risks at “good” cholesterol extremes
In UK Biobank, genetically unexpected low “good” cholesterol carried a relative cardiovascular disease rate of 1.20 versus genetically consistent low levels.In UK Biobank, genetically unexpected low “good” cholesterol carried a relative cardiovascular disease rate of 1.20 versus genetically consistent low levels.
Cohort studyPopulations
Who was studiedEuropean-ancestry participants at HDL cholesterol extremes
What changedCardiovascular disease risk was higher with genetically unexpected versus genetically consistent low HDL in UK Biobank (hazard ratio 1.20)
The catchNon-genetic influences on cholesterol could also drive disease and mortality differences between genetic-discordance groups